Solid state characterization, solubility, intrinsic dissolution and stability behavior of allopurinol hydrochloride salt

Since each solid form of an active pharmaceutical ingredient (API) can exhibit particular physicochemical properties, the objectives this work were to characterize and study solubility/stability properties allopurinol hydrochloride salt (ALO-HCl) for first time. ALO-HCl was obtained through unreported recrystallization process studied by X-ray powder diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC) thermogravimetric analysis (TGA). All characterization techniques effective differentiation from preferred (ALO). DSC TGA studies showed a solid-state conversion ALO upon HCl loss. Solubility dissolution tests that converts in aqueous media. Moreover, effect common ion decreased amount drug released during intrinsic assay medium. The stability partial after 6 months storage. results indicate comparative between crystalline forms APIs are great importance, as they contribute understanding aspects related quality medicines.